The authors identify several types of the new forms of protestmovement that are discusses within the problems of autonomy ofscientific system and the protection of the interests of scientists. They argue that the this type of communication shows how it is possible to combine both cognitive and normative attitude of science. The authors show the mechanisms of the reproduction of this communication and argue that it gradually turns into communicative macro system. The authors conclude that the protest movement in science (...) could be considered as a practical resolution of the Merton – Popper paradox, which presumes the incompatibility of both cognitive attitude (impartial observation) and normative dimension (value production) of science. (shrink)

In this study, voluntary and involuntary visual attention focused on different interpretations of a bistable image, were investigated using magnetoencephalography. A Necker cube with sinusoidally modulated pixels' intensity in the front and rear faces with frequencies 6.67 Hz and 8.57 Hz, respectively, was presented to 12 healthy volunteers, who interpreted the cube as either left- or right-oriented. The tags of these frequencies and their second harmonics were identified in the average Fourier spectra of the MEG data recorded from the visual (...) cortex. In the first part of the experiment, the subjects were asked to voluntarily control their attention by interpreting the cube orientation as either being on the left or right. Accordingly, we observed the dominance of the corresponding spectral component, and voluntary attention performance was measured. In the second part of the experiment, the subjects were asked to focus their gaze on a red marker at the center of the cube image without putting forth effort in its interpretation. The alternation of the dominant spectral energies at the second harmonics of the stimulation frequencies was treated as changes in the cube orientation. Based on the results of the first experimental stage and using a wavelet analysis, we developed a method which allowed us to identify the currently perceived cube orientation. Finally, we characterized involuntary attention using the distribution of dominance times when focusing attention on one of the cube orientations, which was related to voluntary attention performance and brain noise. In particular, we confirmed our hypothesis that higher attention performance is associated with stronger brain noise. (shrink)

The mouthparts of anuran tadpoles are highly derived compared to those of caecilians or salamanders. The suprarostral cartilages support the tadpole's upper beak; the infrarostral cartilages support the lower beak. Both supra‐ and infrarostral cartilages are absent in other vertebrates. These differences reflect the evolutionary origin of a derived feeding mode in anuran tadpoles. We suggest that these unique cartilages stem from the evolution of new articulations within preexisting cartilages, rather than novel cartilage condensations. We propose testing this hypothesis through (...) a search for similarities in the development of the suprarostral and infrarostral cartilage articulations and of the primary jaw joint. In Xenopus, the gene zax is expressed in a region corresponding to the infrarostral cartilage. This gene is related to the bapx1‐gene, which regulates jaw joint development. Further investigation of these genes, as well as other genes with joint‐related functions, in anuran craniofacial development may provide a connection between the morphological diversity seen in the vertebrate head and the corresponding diversity in genetic regulatory processes. We believe that the evolution of larval jaws in anurans may shed light on the general evolutionary mechanisms of how new articulations, not only in the jaw region, could have arisen in the vertebrate skull. BioEssays 27: 526–532, 2005. © 2005 Wiley periodicals, Inc. (shrink)

Digital Earth applications provide a common ground for visualizing, simulating, and modeling real-world situations. The potential of Digital Earth applications has increased significantly with the evolution of artificial intelligence systems and the capacity to collect and process complex amounts of geospatial data. Yet, the widespread techno-optimism at the root of Digital Earth must now confront concerns over high-risk artificial intelligence systems and power asymmetries of a datafied society. In this commentary, we claim that not only can current debates about data (...) governance and ethical artificial intelligence inform development in the field of Digital Earth, but that the specificities of geospatial data, together with the expectations surrounding Digital Earth applications, offer a fruitful lens through which to examine current debates on data governance and artificial intelligence ethics. In particular, we argue that for the implementation of ethical artificial intelligence and inclusive approaches to data governance, Digital Earth initiatives need to involve stakeholders and communities at the local level and be sensitive to social, legal, cultural, and institutional contexts, including conflicts that might arise within those contexts. (shrink)

A special issue of_ New German Critique_ The posthumous publication of Theodor W. Adorno’s works on music continues to reveal the special relationship between music and philosophy in his thinking. These important works have not, however, received as much scholarly attention as they deserve. Contributors to this issue seek to provide insight into some of the key themes raised in these works, including the sociology of musical genre, the historical transformation of music from the "heroic" or high-bourgeois era to late (...) modernity, the meaning of both performance and listening in the era of mass communication, and the specific challenges or deformations of the radio on musical form, a theme that implicates many of the digital practices of our own age. There is much left to discover in these new publications, and they pose again, with renewed vigor, the question of Adorno’s _Aktualität_—his polyvalent, untranslatable term for, among other things, the intellectual relationship between the present and the past. Contributors Daniel K. L. Chua, Lydia Goehr, Peter E. Gordon, Martin Jay, Brian Kane, Max Paddison, Alexander Rehding, Fred Rush, Martin Scherzinger. (shrink)

The authors identify several types of the new forms of protestmovement that are discusses within the problems of autonomy ofscientific system and the protection of the interests of scientists. They argue that the this type of communication shows how it is possible to combine both cognitive and normative attitude of science. The authors show the mechanisms of the reproduction of this communication and argue that it gradually turns into communicative macro system. The authors conclude that the protest movement in science (...) could be considered as a practical resolution of the Merton – Popper paradox, which presumes the incompatibility of both cognitive attitude (impartial observation) and normative dimension (value production) of science. (shrink)

Despite the frequency of stillbirths, the subsequent implications are overlooked and underappreciated. We present findings from comprehensive, systematic literature reviews, and new analyses of published and unpublished data, to establish the effect of stillbirth on parents, families, health-care providers, and societies worldwide. Data for direct costs of this event are sparse but suggest that a stillbirth needs more resources than a livebirth, both in the perinatal period and in additional surveillance during subsequent pregnancies. Indirect and intangible costs of stillbirth are (...) extensive and are usually met by families alone. This issue is particularly onerous for those with few resources. Negative effects, particularly on parental mental health, might be moderated by empathic attitudes of care providers and tailored interventions. The value of the baby, as well as the associated costs for parents, families, care providers, communities, and society, should be considered to prevent stillbirths and reduce associated morbidity. (shrink)

Few studies have examined how trait emotion dysregulation relates to momentary affective experiences and the emotion regulation strategies people use in daily life. In the current study, 112 c...

In the paper, a detailed analysis of some new logical aspects of Cantor’s diagonal proof of the uncountability of continuum is presented. For the first time, strict formal, axiomatic, and algorithmic definitions of the notions of potential and actual infinities are presented. It is shown that the actualization of infinite sets and sequences used in Cantor’s proof is a necessary, but hidden, condition of the proof. The explication of the necessary condition and its factual usage within the framework of Cantor’s (...) proof makes, Cantor’s proof invalid. It’s shown that traditional Cantor’s proof has a second necessary, but hidden as well, condition which is teleological by its nature, i.e., is not mathematical. The explication of the second necessary condition makes Cantor’s statement on the uncountability of continuum unprovable from the point of view of classical logic.One of the most dramatic facts in history of science is connected just with the notion of actual infinity and consists in the following. On the one hand, Aristotle, Berkeley, Locke, Descartes, Spinoza, Gauss, Kant, Cauchy, Kronecker, Hermite, Poincaré, Bair, Borel, Brouwer, Quine, Wittgenstein, Weyl, Luzin, and a lot of other outstanding creators of classical logic and classical mathematics, during millenniums, stated categorically and insistently warned about that the actual infinity is a self-contradictory notion and its usage in mathematics is inadmissible (e.g., according to Poincare, “There is no actual infinity. - Cantorians forgot that and fell into contradictions. Later generations will regard Mengenlehre (set theory) as a disease from which one has recovered”). On the other hand, a lot of outstanding scientists of the XX c.c., such as Hilbert, Church, Turing, Gödel, etc., and modern axiomatic set theory as a whole ignored this (intuitive though) opinion of genii and accepted Cantor’s “transfinite paradise”, based on the actual infinity. In the paper some logical, philosophical, and psychological aspects of this historical “favorable opposition” are analyzed, and the fact that the scientific intuition of genii has won the historical battle against the mytho-’logic’ of Cantor’s transfinite ‘paradise’ is explained and logically justified. (shrink)

The article attempts to develop the methodological foundations of innovation as a new field of scientific research that studies innovation in science, culture and society. On the basis of the philosophical and methodological approach, the term “innovation” is conceptualized. The definition of the concept of innovation proposed in the article is based on the “procedural approach” in the interpretation of innovation activity and at the same time emphasizes the significance of the final result in the form of a new product (...) that has commercial (social) value. In the context of modern trends in technogenic civilization, the essential features of innovative activity are revealed, its high degree of uncertainty and sensitivity to random changes and the influence of the external environment is revealed, it is shown that, along with organization, self-organization processes play an important role in it, manifested in complex, spontaneous changes accompanying the emergence of innovations. It is concluded that these features are evidence of the synergistic nature of innovation. The “rehabilitation” of synergetics is being carried out, which is considered as an ontological basis for building an innovative methodology. The article also formulates the basic principles of innovation methodology: openness of innovation, unity of linearity and non-linearity, probabilistic nature, the principle of systemic communication and organization, interdisciplinarity, the principle of relying on feedback. The possibility of creating an innovative method is being assessed. On this basis, the modern status of innovation is determined as an independent field of knowledge that has its own object, subject, functions, subjects, methodology, social mechanisms and the sphere of innovative consciousness, as well as other distinctive features of any particular science. A new approach to understanding the social and humanitarian expertise of high-risk innovative projects is proposed. (shrink)

After a vertebrate dies, many of its organ systems, tissues, and cells remain functional while its body no longer works as a whole. We define this state as the “twilight of death” − the transition from a living body to a decomposed corpse. We claim that the study of the twilight of death is important to ethical, legal and medical science. We examined gene expression at the twilight of death in the zebrafish and mouse reaching the conclusion that apparently thousands (...) of transcripts significantly increase in abundance from life to several hours/days postmortem relative to live controls. Transcript dynamics of different genes provided “proof-of-principle” that models accurately predict an individual's elapsed-time-of-death. While many transcripts were associated with survival and stress compensation, others were associated with epigenetic factors, developmental control, and cancer. Future studies are needed to determine whether the high incidence of cancer in transplant recipients is due to the postmortem processes in donor organs. In organismal death, some organ systems, tissues and cells remain functional while the body no longer works as a whole. In the “twilight of death” − the transition from a living body to a decomposed corpse − thousands of gene transcripts increase in abundance relative to live controls. (shrink)

This article is dedicated to the 30th anniversary of the publication of Niklas Luhmann’s book The Science of Society. The system-communicative approach to the analysis of science is reconstructed with a focus on the relation of science to its highly complex external world. The problem of complexity is posed as a key one and is considered in the context of the communicative “reduction of the complexity” of the external world, which science actualizes through its unique binary opposition (truth/falsehood distinction). The (...) complexity of the world that science is facing disintegrates into two large areas. On the one hand, science processes its own external world, i.e., nature, society, the human psyche, as its object and thus fulfills a unique function, the pursuance of research. Scientific communication in this case can be integrated in the form of transdisciplinary studies. On the other hand, science has to respond to the complexity of the internal (i.e., social) external world of the communicative system of science, namely, to interfaced communicative systems of the embracing system of world society (politics, economy, religion, education, law, etc.). In the latter case, science does not fulfill a function but delivers achievements on request to the above-mentioned communicative systems in exchange for resources for interdisciplinary studies, which are occasional and cannot serve for integrating scientific communication on a systematic basis. We will propose some corrections to this theory and apply it to the situation in Russian science. (shrink)

Browning has put together a useful anthology of texts taken from Bergson, Peirce, James, Alexander, Morgan, Dewey, Mead, and Whitehead, and arranged around the common allegiance of these philosophers to a "metaphysics of motion" as opposed to a classical "metaphysics of rest." The metaphysical presuppositions of at least one form of process philosophy are delineated in a remarkably concise and coherent introduction by Charles Hartshorne: one is tempted to call this introduction Hartshorne's Monadology. The editor provides an illuminating historical (...) account of the genesis of process philosophy in his preface, and has included a brief biographical introduction and a well-selected and current bibliography for each philosopher.—E. A. R. (shrink)

A discussion of the notion of infinity as it appears in the prototype of the great Summae of the thirteenth century, the Summa Fratris Alexandri, traditionally ascribed to Alexander of Hales but now known to be a compilation by the monks at the Paris house of the Franciscans to which Alexander belonged. This Summa reveals the initial effects of the Aristotelian analysis upon the then dominant Neo-Platonic, Augustinian and Anselmian Illuminationisms, and its relation to the philosophical notion of (...) an infinite God. As Wass stresses, the notion of infinity systematically expounded in this Summa provided the conceptual framework for most of the subsequent medieval speculation on the subject.—E. A. R. (shrink)

An increasing number of research teams are investigating the efficacy of brain-computer interface (BCI)-mediated interventions for promoting motor recovery following stroke. A growing body of evidence suggests that of the various BCI designs, most effective are those that deliver functional electrical stimulation (FES) of upper extremity (UE) muscles contingent on movement intent. More specifically, BCI-FES interventions utilize algorithms that isolate motor signals—user-generated intent-to-move neural activity recorded from cerebral cortical motor areas—to drive electrical stimulation of individual muscles or muscle synergies. BCI-FES (...) interventions aim to recover sensorimotor function of an impaired extremity by facilitating and/or inducing long-term motor learning-related neuroplastic changes in appropriate control circuitry. We developed a non-invasive, electroencephalogram (EEG)-based BCI-FES system that delivers closed-loop neural activity-triggered electrical stimulation of targeted distal muscles while providing the user with multimodal sensory feedback. This BCI-FES system consists of three components: (1) EEG acquisition and signal processing to extract real-time volitional and task-dependent neural command signals from cerebral cortical motor areas, (2) FES of muscles of the impaired hand contingent on the motor cortical neural command signals, and (3) multimodal sensory feedback associated with performance of the behavioral task, including visual information, linked activation of somatosensory afferents through intact sensorimotor circuits, and electro-tactile stimulation of the tongue. In this report, we describe device parameters and intervention protocols of our BCI-FES system which, combined with standard physical rehabilitation approaches, has proven efficacious in treating UE motor impairment in stroke survivors, regardless of level of impairment and chronicity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Diacritics 31.4 (2001) 11-21 [Access article in PDF] Alphonso Lingis's We—A Collage, not a Collective Alexander E. Hooke Alphonso Lingis. Abuses. Berkeley: U of California P, 1994. [AB]________. The Community of Those Who Have Nothing in Common. Bloomington: Indiana UP, 1994. [COMM]________. Dangerous Emotions. Berkeley: U of California P, 2000. [DE]________. Foreign Bodies.New York: Routledge, 1994. [FB]________. The Imperative Bloomington: Indiana UP, 1998. [IMP] For Walt Fuchs 1 (...) Alphonso Lingis is unabashed in his uses of we. He does not speak about a privileged we, an exemplary or hegemonic we, or "we." According to this American philosopher, the various ways critics qualify their references to first person plural (we, us, our) are unnecessary, if not unjustifiable. Their caution and skepticism about any direct use of we invariably lead one to focus on this important pronoun as if it were a rhetorical sleight of hand, an ironic twist, a sign of embarrassment or elitism. Worse, their gradual cynicism diminishes or derides the reality of those whose contact with others can only be articulated in terms of we or our. Thus readers, and students subject to these theoretical reservations, are tempted to circumvent any substantive meaning to first-person plural in their own reflections and research. Given the persuasive charms of these reservations, to admit a genuine or lived we involves the risk of being charged with superficiality, a lack of sophistication, nostalgia, or political naiveté. 1In the face of this risk, Lingis writes in first-person plural without apology. Seemingly oblivious to the ongoing controversies over any legitimate use of we—as if it connoted self-indulgence or self-delusion, Lingis depicts experiences and contacts that embody a substance to first-person plural. These contacts are presented directly and with little hesitation, as they often move one to awaken to daring, brazen, or unfamiliar individuals in their contexts and surroundings. To present them requires an air of innocence to the extent that the contacts appear as new to the writer as they are to the reader. [End Page 11]They encompass more than surprise and spectacle. They also initiate beliefs and emotions that embrace other truths: unfamiliar expressions of gods, strange forms of human commitments, eccentric relations humans have with the past and future, but also with animals, trees, and unseen spirits. These truths evoke the kinds of genuine goods and values that are better conceived not as potential instantiations or counterexamples to our generalizations and conventions, but rather as compelling additions to our own senses of reality and truth.In writing about we or us, however, Lingis also raises some critical stakes. While conversant with most of the influential figures and themes discussed under the postmodern rubric, Lingis extends their central ideas to new levels and fields of inquiry. Instead of scrutinizing the uses of first-person plural or maintaining a respectable distance from them, his philosophical endeavors are distinct insofar as they address: How do we, he and his audience, respond to the many kinds of contact that are readily dismissed insofar as they overlooked in our scholarly and philosophical endeavors? What might these other uses and realities of the first-person plural say that affirm, question, or contest us? Can his own work, lucidly presented in five recent books, contribute to contemporary discussions about the possibilities and pitfalls of human relations, cultural and political entities, social and biological communities, and the theoretical or critical reflections on them? 2 Lingis's answers are guided by looking at we more as a collage and less as a collective. A collage, unlike a collection, emphasizes or highlights the unpredictable ways that humans and other life forms come together. The use of we as a collective—whether the result of unconscious drives, chosen ideologies, an intersubjective ethic, or rational communication acts—emphasizes certain values, particularly those that help us to distinguish whether the experiences of we can be understood or appreciated in terms of true or false, good or bad, genuine or superficial, beautiful or ugly, familiar and significant terms for making judgments about moral, social, and... (shrink)

ObjectiveIn this study we used functional magnetic resonance imaging to investigate whether motor imagery of handwriting and circle drawing activates a similar handwriting network as writing and drawing itself.MethodsEighteen healthy right-handed participants wrote the German word “Wellen” and drew continuously circles in a sitting and lying position to capture kinematic handwriting parameters such as velocity, pressure and regularity of hand movements. Afterward, they performed the same tasks during fMRI in a MI and an executed condition.ResultsThe kinematic analysis revealed a general (...) correlation of handwriting parameters during sitting and lying except of pen pressure during drawing. Writing compared to imagined writing was accompanied by an increased activity of the ipsilateral cerebellum and the contralateral sensorimotor cortex. Executed compared to imagined drawing revealed elevated activity of a fronto–parieto-temporal network. By contrasting writing and drawing directly, executed writing induced an enhanced activation of the left somatosensory and premotor area. The comparison of the MI of these tasks revealed a higher involvement of occipital activation during imagined writing.ConclusionThe kinematic results pointed to a high comparability of writing in a vertical and horizontal position. Overall, we observed highly overlapping cortical activity except of a higher involvement of motor control areas during motor execution. The sparse difference between writing and drawing can be explained by highly automatized writing in healthy individuals. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

In the paper, a detailed analysis of some new logical aspects of Cantor’s diagonal proof of the uncountability of continuum is presented. For the first time, strict formal, axiomatic, and algorithmic definitions of the notions of potential and actual infinities are presented. It is shown that the actualization of infinite sets and sequences used in Cantor’s proof is a necessary, but hidden, condition of the proof. The explication of the necessary condition and its factual usage within the framework of Cantor’s (...) proof makes, Cantor’s proof invalid. It’s shown that traditional Cantor’s proof has a second necessary, but hidden as well, condition which is teleological by its nature, i.e., is not mathematical. The explication of the second necessary condition makes Cantor’s statement on the uncountability of continuum unprovable from the point of view of classical logic.One of the most dramatic facts in history of science is connected just with the notion of actual infinity and consists in the following. On the one hand, Aristotle, Berkeley, Locke, Descartes, Spinoza, Gauss, Kant, Cauchy, Kronecker, Hermite, Poincaré, Bair, Borel, Brouwer, Quine, Wittgenstein, Weyl, Luzin, and a lot of other outstanding creators of classical logic and classical mathematics, during millenniums, stated categorically and insistently warned about that the actual infinity is a self-contradictory notion and its usage in mathematics is inadmissible (e.g., according to Poincare, “There is no actual infinity. - Cantorians forgot that and fell into contradictions. Later generations will regard Mengenlehre (set theory) as a disease from which one has recovered”). On the other hand, a lot of outstanding scientists of the XX c.c., such as Hilbert, Church, Turing, Gödel, etc., and modern axiomatic set theory as a whole ignored this (intuitive though) opinion of genii and accepted Cantor’s “transfinite paradise”, based on the actual infinity. In the paper some logical, philosophical, and psychological aspects of this historical “favorable opposition” are analyzed, and the fact that the scientific intuition of genii has won the historical battle against the mytho-’logic’ of Cantor’s transfinite ‘paradise’ is explained and logically justified. (shrink)

Twilight Zone and Philosophy attempts to bring the insights and paradoxes of Rod Serling's project to contemporary audiences through a variety of philosophical perspectives"--Publisher.

This paper reviews the actual and potential use of social media in emergency, disaster and crisis situations. This is a field that has generated intense interest. It is characterised by a burgeoning but small and very recent literature. In the emergencies field, social media (blogs, messaging, sites such as Facebook, wikis and so on) are used in seven different ways: listening to public debate, monitoring situations, extending emergency response and management, crowd-sourcing and collaborative development, creating social cohesion, furthering causes (including (...) charitable donation) and enhancing research. Appreciation of the positive side of social media is balanced by their potential for negative developments, such as disseminating rumours, undermining authority and promoting terrorist acts. This leads to an examination of the ethics of social media usage in crisis situations. Despite some clearly identifiable risks, for example regarding the violation of privacy, it appears that public consensus on ethics will tend to override unscrupulous attempts to subvert the media. Moreover, social media are a robust means of exposing corruption and malpractice. In synthesis, the widespread adoption and use of social media by members of the public throughout the world heralds a new age in which it is imperative that emergency managers adapt their working practices to the challenge and potential of this development. At the same time, they must heed the ethical warnings and ensure that social media are not abused or misused when crises and emergencies occur. (shrink)

This article examines one of the relevant concepts in the current debate on home birth—autonomy in place of birth—and its uses in general language, ethics, and childbirth health care literature. International discussion on childbirth services. A concept analysis guided by the model of Walker and Avant. The authors suggest that autonomy in the context of choosing place of birth is defined by three main attributes: information, capacity and freedom; given the antecedent of not harming others, and the consequences of accountability (...) for the outcome. Model, borderline and contrary cases of autonomy in place of birth are presented. A woman choosing place of birth is autonomous if she receives all relevant information on available choices, risks and benefits, is capable of understanding and processing the information and choosing place of birth in the absence of coercion, provided she intends no harm to others and is accountable for the outcome. The attributes of the definition can serve as a useful tool for pregnant women, midwives, and other health professionals in contemplating their moral status and discussing place of birth. (shrink)

???Everyone agrees that the moral features of things supervene on their natural features??? , 22). Everyone is wrong, or so I will argue. In the first section, I explain the version of moral supervenience that Smith and others argue everyone should accept. In the second section, I argue that the mere conceptual possibility of a divine command theory of morality is sufficient to refute the version of moral supervenience under consideration. Lastly, I consider and respond to two objections, showing, among (...) other things, that while DCT is sufficient to refute this version of moral supervenience it is not necessary. (shrink)

The living mycelium networks are capable of efficient sensorial fusion over very large areas and distributed decision making. The information processing in the mycelium networks is implemented via propagation of electrical and chemical signals en pair with morphological changes in the mycelium structure. These information processing mechanisms are manifested in experimental laboratory findings that show that the mycelium networks exhibit rich dynamics of neuron-like spiking behaviour and a wide range of non-linear electrical properties. On an example of a single real (...) colony of _Aspergillus niger_, we demonstrate that the non-linear transformation of electrical signals and trains of extracellular voltage spikes can be used to implement logical gates and circuits. The approaches adopted include numerical modelling of excitation propagation on the mycelium network, representation of the mycelium network as a resistive and capacitive network and an experimental laboratory study on mining logical circuits in mycelium bound composites. (shrink)

The tides of change constantly surface new currents in the world of business. No longer is it sufficient to seek the static positional advantage offered by classical Porterian analysis. This article explores the emerging direction of business strategy as expressed by the concept of evolutionary advantage. It examines first the major forms of business knowledge over the last century, then considers mainstream frameworks for strategic analysis, and offers, as a compelling alternative, the emerging notions of evolutionary development and evolutionary learning. (...) Through application of Evolutionary Systems Design, it is shown how an organization may cultivate strategies for sustainable success. (shrink)

In this article, the authors explore the impact of a potential future regulatory decision by FDA whether or not to continue its enforcement discretion policy allowing physicians to perform, and stool banks to sell, stool product for fecal microbiota transplantation as a treatment for recurrent Clostridium Difficile infection without an Investigative New Drug application. The paper looks at the Agency's regulatory options in light of the current gut microbiota based products that are in the FDA pipeline for drug approval and (...) the potential impact and repercussions of their approval on FDA action. In laying out FDA's options we consider the implications of market exclusivity and off-label use of newly approved drugs. Ultimately, we explore the potential impact of FDA's decision on patients, research, and innovation. (shrink)

'Everyone agrees that the moral features of things supervene on their natural features' (Smith (1994), 22). Everyone is wrong, or so I will argue. In the first section, I explain the version of moral supervenience that Smith and others argue everyone should accept. In the second section, I argue that the mere conceptual possibility of a divine command theory of morality (DCT) is sufficient to refute the version of moral supervenience under consideration. Lastly, I consider and respond to two objections, (...) showing, among other things, that while DCT is sufficient to refute this version of moral supervenience it is not necessary. (shrink)

In a city high school recently a male student completed a one day suspension for fighting with a female student. It was the only day of school he missed and the only time he got into trouble. When he returned to sit in his usual place, which was next to the female student, the teacher soon noticed and suggested the male student move to another seat. The student said this was his usual seat, he was comfortable there, and wanted to (...) know why he had to move. The teacher insisted, the student resisted, until the teacher called in the principal and security guard. After trying to persuade the student, they said, “We'll have to arrest you”; and he replied, “So?” The student was arrested. The teacher did not attempt to discuss the suggestions with the student nor ask other faculty for assistance. By being arrested and too poor to post bond, the student had to spend two nights in the city jail. Unsurprisingly, this notorious building induced greater fear in the student, whose cellmate was a convicted murderer, than any nagging public school teacher could; still, the student forced himself to stay awake for two consecutive nights. Sending a student to jail for not switching seats strikes one as insane. Even though this incident may not be typical, one should be cautioned about drawing the conclusion that it was only a freak occurrence. The insanity followed a rational routine: Teacher makes request to student; student says no, hence disobeys; teacher gives warning, calls in authorities; authorities give warning, arrest student; student goes to jail. Indeed, the final action follows a sequence in which no outlandish violation of the rules appeared. A combination of regulations, circumstances, and individuals invested with power make this insanity readily possible. And yet, as one observer put it, it could have been avoided, “All they had to do was treat him as a human being.”1. (shrink)

The variation in genome size and basic chromosome number was analyzed in the wide range of angiosperm plants. A divergence of monocots vs. dicots (eudicots) genome size distributions was revealed. A similar divergence was found for annual vs. perennial dicots. The divergence of monocots vs. dicots genome size distributions holds at different taxonomic levels and is more pronounced for species with larger genomes. Using nested analysis of variance, it was shown that putative constraints on genome size variation are not only (...) stronger in dicots as compared to monocots but in the former they start to operate already at the family level, whereas in the latter they do so only at the order level. At the same time, variation in basic chromosome number is constrained at the order level in both groups. Higher basic chromosome numbers were found in perennial plants as compared to the annual ones, which can be explained by their need for a higher genetic recombination as compensation for the longer life-cycles. A negative correlation was found between genome size and basic chromosome number, which can be explained as a trade-off between different recombination mechanisms. (shrink)

An explanation of the inter-gender difference in longevity consistent with the 'disposable soma' theory of ageing is proposed. It is based on the concept of r-K selection as applied to the inter-gender situation. The concept predicts that the gender with a higher potential reproductive rate (males) should invest relatively less in somatic maintenance, which in its turn should result in a lower longevity according to the 'disposable soma' theory of ageing. In females, which are interpreted as K-selected organisms, the reproductive (...) strategy strongly depends on steady, secure constitution designed for oocyte/embryo bearing and is therefore closely related to somatic maintenance, whereas in (r-selected) males it has a greater behavioural component - risky, variable, with a greater potential reproductive success at the expense of somatic maintenance. The higher metabolic and growth rates, a higher premature mortality and a longer period of sexual competence of males also find explanation as a complex of r-selected traits. (shrink)